1P226 Single-molecule imaging study of signal transduction mechanism on Akt(13E. Biological & Artifical membrane: Signal transduction,Poster)

Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral

RalGDS is one of the Ras effectors and functions as a guanine nucleotide exchange factor for the small G-protein, Ral, which regulates membrane trafficking and cytoskeletal remodeling. The translocation of RalGDS from the cytoplasm to the plasma membrane is required for Ral activation. In this study, to understand the mechanism of Ras-Ral signaling we performed a single-molecule fluorescence an...

Systems biological analyses of intracellular signal transduction

Mechanism of Interleukin 2-Induced Signal Transduction

Address for Correspondence : Hironobu Asao, Department of Immunology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan Extensive studies on the IL-2 and IL-2 receptor system have established fundamental principles of immune responses and signal transducing mechanisms of hematopoietic cell proliferation and survival. IL-2Rb and IL-2Rg chains are associated with ...

The mechanism of hedgehog signal transduction.

Hedgehog (Hh) proteins are one of a small number of families of secreted signalling proteins that are responsible for cell interactions during development in many animals. As such, Hh signals produce many different responses at different times and in different cells. As for other multifunctional ligands, this requires regulated patterns of expression, special mechanisms for ligand movement betw...

The mechanism of IL-5 signal transduction.

Cytokines are important regulators of hematopoiesis. They exert their actions by binding to specific receptors on the cell surface. Interleukin-5 (IL-5) is a critical cytokine that regulates the growth, activation, and survival of eosinophils. Because eosinophils play a seminal role in the pathogenesis of asthma and allergic diseases, an understanding of the signal transduction mechanism of IL-...